When Safe lane trading and poke

1. QShred→
2. AutoBasic attack→
3. ESlow

Tip Q reduces the target's armor and magic resistance by 20%, increasing the damage of the following basic attacks and E. E's ooze trail then controls the escape path or creates space for a disengage.

When Committing to an all-in while W provides additional range

1. WEmpower→
2. QShred→
3. AutoBasic attack→
4. AutoBasic attack→
5. ESlow→
6. AutoBasic attack

Tip Turn on W first for bonus range and maximum-health on-hit damage, then Q shred and basic attack. If they run, catch with E slow and finish with basic attacks.

When Kiting while maintaining sustained damage

1. WEmpower→
2. AutoBasic attack→
3. EWeave→
4. AutoBasic attack→
5. QWeave→
6. AutoBasic attack

Tip Cast E or Q immediately after a basic attack lands, then reposition during the ability animation. W supplies the on-hit damage, E slows, and Q reduces defenses; because Kog'Maw has no dash, the spacing between each attack and spell determines whether the target can close the gap.

When Long-range sniping low-health targets from safety

1. RFirst→
2. RAmplify→
3. RFinish

Tip R scales with the target's missing health and deals double damage below 40% health. Repeated casts do not increase its damage; only the mana cost stacks for 8 seconds, so lead the low-health target's path and fire only as many shots as needed.