When Zed all-ins with Death Mark (R), Lissandra self-casts Frozen Tomb (R) to freeze and nullify the burst, then cuts his Shadow Slash (E) combo with Ring of Frost (W) root and the targeted Frozen Tomb (R) stun.

Ring of Frost (W)'s AoE root and the targeted Frozen Tomb (R) instantly interrupt Katarina's Death Lotus (R) channel, shutting down her resets.

Even when Talon all-ins with Rake (W) and Shadow Assault (R), Lissandra self-casts Frozen Tomb (R) to nullify the burst, then locks him down with Ring of Frost (W) root and turns it around.

Frozen Tomb (R) is a targeted cast that Wind Wall (W) can't block, while Ring of Frost (W) root and Ice Shard (Q) poke keep cutting off Yasuo's engages.

Even as Yone dives with Soul Unbound (E) and the third Mortal Steel (Q), the targeted Frozen Tomb (R) locks in a guaranteed stun, and self-casting Frozen Tomb (R) rides out his Fate Sealed (R) burst.

Sanguine Pool (W) dodges Lissandra's Ring of Frost (W) root and Frozen Tomb (R) stun, and Transfusion (Q)'s strong lifesteal sustain shrugs off Ice Shard (Q) poke to hold the lane.

Null Sphere (Q)'s magic shield absorbs Ice Shard (Q) and Ring of Frost (W) poke, and Riftwalk (R) lets him scale outside Lissandra's short range before overwhelming her in the late game.

Long-range Bouncing Bomb (Q) poke and Hexplosive Minefield (E) AoE waveclear chip Lissandra down before she can close in and shove the lane to shut down even her roams.

Plasma Fission (Q) and Void Rift (W) deal sustained damage from beyond Lissandra's range, and Tectonic Disruption (E)'s knockup interrupts her Glacial Path (E) engage.