Kayle's range and damage are weak until her ultimate comes online, so Lux pressures throughout the lane with a Light Binding (Q)-Lucent Singularity (E)-auto combo and hunts for solo kills before Divine Judgment (R) is available.

Nasus is melee and must walk up to farm, so Lux disrupts his CS with long-range Lucent Singularity (E) and Light Binding (Q) and denies his Siphoning Strike (Q) stacks through constant poke.

Aurelion Sol has low early range and damage and scales through his Cosmic Creator (P) stacks, so Lux presses hard early with Light Binding (Q) combos to delay his stack growth.

Veigar has no mobility, so he is fully exposed to Lux's longer early-game poke, and once caught by Light Binding (Q) he takes heavy damage from the full combo.

Zed dodges Lux's Light Binding (Q) and Final Spark (R) skillshots with Living Shadow (W) and Death Mark (R), then closes in and bursts the squishy Lux down in one combo.

Fizz becomes untargetable with Playful (E) to dodge Lux's Light Binding (Q) and Final Spark (R), then instantly kills her with his Chum the Waters (R) shark combo.

After his ultimate, Kassadin uses Riftwalk (R) to dodge all of Lux's skillshots and repeatedly blinks onto her, all-inning the immobile Lux endlessly.

Wind Wall (W) blocks Light Binding (Q) and Lucent Singularity (E) while they travel, but it cannot block Final Spark (R). Yasuo can close with Sweeping Blade (E) after denying Q and E, while still dodging the ultimate beam directly.

Katarina dodges Lux's skillshots and closes in with Shunpo (E) and Flash, then uses her Voracity (P) resets to burst down the squishy Lux in an instant.