When Safe laning poke to win trades and gain a health lead

1. ECharged→
2. QHeal

Tip Charging E for up to 1.5 seconds can double its damage but also costs Vladimir's health. Release before the target leaves and recover some health with Q; charging beyond 1 second slows Vladimir, so this is safer against an approaching enemy than during a chase.

When Bursting a target or applying Hemoplague across a grouped fight

1. RAmplify→
2. ECharged→
3. Q→
4. WDodge→
5. ERecharge

Tip Land R first so 10% of the damage dealt during its 4-second infection is added to the explosion, then fit E and Q into that window. Use W's 2 seconds of untargetability against the key retaliation, stay under the target for its damage and slow, and buy time for the next E before R detonates.

When Strong trade when a Crimson Rush stack is ready

1. ECharged→
2. QCrimson Rush→
3. WReposition→
4. E

Tip Each completed Q cooldown adds Bloodthirst, and two stacks grant Crimson Rush for 2.5 seconds, heavily empowering the next Q. Use that Q on a champion before the state expires for damage and missing-health healing, dodge retaliation with W, then charge E according to the health Vladimir can afford.