Before Demon Shade (P) stealth unlocks at level 5, Evelynn has weak early clears and duels and a squishy body, so Kha'Zix sticks on with Void Spike (W)'s slow and deletes the isolated target with Taste Their Fear (Q).

Lillia is a damage-over-time kiter with no burst or reliable escape, so Kha'Zix closes in with evolved Leap (E) and melts her with an isolated Taste Their Fear (Q) combo.

Kindred is a squishy ranged jungler, so when Lamb's Respite (R) is on cooldown Kha'Zix bursts her with evolved Leap (E) into an isolated Taste Their Fear (Q) before she can activate it.

Twitch has no defensive or escape tool for melee fights, so Kha'Zix chases his Ambush (Q) stealth movement with Leap (E) and finishes him with isolated burst.

Warwick sustains through Jaws of the Beast (Q) lifesteal, detects and speeds toward a low-health Kha'Zix with Blood Hunt (W), and cuts off the Leap (E) assassination combo with Infinite Duress (R)'s suppression.

Rammus reflects Kha'Zix's AD burst with Defensive Ball Curl (W) and thornmail, and locks him down with Powerball (Q) speed and Frenzying Taunt (E), making a straight duel heavily unfavorable.

Xin Zhao is a top-tier early duelist who overwhelms early skirmishes with Wind Becomes Lightning (W)'s AoE poke and slow, Three Talon Strike (Q)'s third-hit knock-up, and Crescent Guard (R)'s knock-back, countering Kha'Zix's assassination combo.

Graves has heavy point-blank shotgun burst from New Destiny (P) and combat-stacking base resistances that make him tanky, giving him a clear edge over Kha'Zix in an early face-to-face 1v1.