Wither (W) slows both Yasuo's attack and movement speed, neutralizing his damage and mobility, while Nasus stacks Siphoning Strike (Q) to grow tanky and dominate extended duels.

Wither (W) likewise kills Yone's attack and movement speed, erasing his sustained damage, while Nasus pushes with Spirit Fire (E) and stacks Siphoning Strike (Q) to crush him late.

Katarina is squishy, so a single Wither (W) collapses her reset-driven dagger combo; Nasus harasses and clears waves with Spirit Fire (E) and can shut her down instantly with Wither (W) even mid Death Lotus (R).

Talon's burst and mobility are fully locked down by Wither (W), while Nasus tanks up and uses Spirit Fire (E)'s damage-over-time to block his Assassin's Path (E) stealth approach.

The moment Zed all-ins with his Living Shadow (W) combo, Wither (W) locks his attack and movement speed, cutting off both his damage and re-engage, while Nasus survives with Fury of the Sands (R) and counters.

Lux pokes melee Nasus from range with Light Binding (Q) and the Lucent Singularity (E) zone; lacking a gap-closer, Nasus fails to farm CS and stack Siphoning Strike (Q) and falls behind.

Ziggs shoves the wave with Bouncing Bomb (Q) and Satchel Charge (W), stealing Nasus's last hits to choke his Siphoning Strike (Q) stacking, while long-range poke keeps him away.

Teemo's Blinding Dart (Q) nullifies Nasus's core Siphoning Strike (Q) empowered auto, and he kites with Toxic Shot (P)'s poison to harass melee Nasus endlessly.

Veigar cages Nasus with the Event Horizon (E) prison and pokes with Baleful Strike (Q) and Dark Matter (W); unable to close in, Nasus lets him scale infinitely via Phenomenal Evil Power (P).

Vel'Koz whittles melee Nasus from a safe distance with Plasma Fission (Q), Void Rift (W), and Tectonic Disruption (E), and denies his Siphoning Strike (Q) stacking through lane control.