Seraphine wins the trade with Q note poke and her charm ult, and Soraka's lack of mobility leaves her fully exposed to Seraphine's burst.

Seraphine's Q outranges Sona's poke and her E can root as a punish; both are immobile but Seraphine's single-hit burst is higher.

Milio is a pure enchanter with no kill threat, so Seraphine takes lane and fight tempo with long-range poke and her ult initiation.

The moment Yuumi detaches to cast, she gets hit by Seraphine's long-range Q and E root, forcing repeated losses.

After Leona's E dash into her Q and R chain CC, the immobile Seraphine is locked down and bursted.

Once caught by Nautilus's Q hook, passive root, and ult chain CC, Seraphine has no way to escape.

If hooked by Blitzcrank's Q Rocket Grab, the squishy immobile Seraphine dies instantly.

Pyke pulls Seraphine with Bone Skewer (Q), chains Phantom Undertow (E)'s stun, and finishes her at low health with Death From Below (R). Ghostwater Dive (W) also lets him extend that pressure through roams.

Seraphine gets caught and killed by Thresh's Q Death Sentence hook and E flay engage with no mobility to escape.