Before Nasus stacks Siphoning Strike (Q), pin him into a wall with Ixtal's Impact (E) to stun and lock him down with Impale (R) for winning trades and lane control.

Before Kassadin gains Riftwalk (R), exploit his weak melee phase with an Ixtal's Impact (E) into Impale (R) all-in to dominate lane.

Slam the mobility-less mage into a wall with Ixtal's Impact (E) to stun, then crush him with Impale (R) suppression.

Before Kayle's level 9 spike, punish her squishy melee weakness early with an Ixtal's Impact (E) all-in for heavy pressure.

Pin him with an Ixtal's Impact (E) wall stun to shut down Poison Trail (Q) kiting, and block his Fling (E) plays with Impale (R) suppression.

She kites autos with Tumble (Q), knocks you into a wall with Condemn (E), and melts tanks with Silver Bolts (W) true damage, denying any approach.

Blinding Dart (Q) nullifies your auto-based Shattered Earth (Q) damage, and Toxic Shot (P) ranged poison zoning blocks any approach.

Riposte (W) negates Ixtal's Impact (E) and Impale (R), while Duelist's Dance (P) vital true damage ignores armor for dueling superiority.

Shock Blast (Q) ranged poke and Thundering Blow (E) knockback keep you at a distance, leaving no way to close in.

Thundering Shuriken (Q) ranged harass and Lightning Rush (E) mobility kite you, and even on approach Mark of the Storm (P) stun chains punish you back.