Vayne also has short range and a weak early game, so Twitch uses Ambush (Q) stealth to ignore her Condemn (E) angle, engages first, and detonates Deadly Venom (P) stacks with Contaminate (E) to win early skirmishes.

Twitch has no mobility besides Ambush (Q) and is squishy, so Smolder's Super Scorcher Breath (Q) poke chips his health, pushing him off the lane and into danger before his Spray and Pray (R) timing.

Twitch also has short early range and lacks laning poke, so a Kog'Maw with Bio-Arcane Barrage (W) active outranges him and pokes freely.

Twitch has weak lane presence before his Ambush (Q) engage, and Jinx's Switcheroo! (Q) rocket mode outranges him, letting her chip his health before he can stack Deadly Venom (P).

Caitlyn's 650 range plus Yordle Snap Trap (W) and Headshot (P) poke push Twitch out of lane and chip his health before he can find an Ambush (Q) engage angle.

Draven's Spinning Axe (Q) empowered autos give him overwhelming early skirmish damage, so a squishy early Twitch with no Deadly Venom (P) stacks simply cannot trade.