Ultless Kayle is defenseless up close, so at levels 3-5 dash in with Lunar Rush (E) and dive with a Crescent Strike (Q)-Moonfall (R) all-in to shut down her scaling.

Poke with Crescent Strike (Q) to disrupt his Siphoning Strike (Q) stack farming, then overwhelm with a Lunar Rush (E)-Moonfall (R) burst all-in before level 5.

Kassadin is fragile before level 5, so a Crescent Strike (Q)-Lunar Rush (E)-Moonfall (R) burst combo pre-empts him before his Riftwalk (R) power spike.

Dash in with Lunar Rush (E) to interrupt the mobility-less Ryze's Overload (Q) casts and burst him down.

As an AP damage dealer she ignores Malphite's armor, and tanks his Seismic Shard (Q) poke with the Pale Cascade (W) shield to stay ahead.

Riposte (W) parry negates Lunar Rush (E) and Moonfall (R) engages, and vitals plus Bladework (E) true damage crush the duel.

The low-cooldown Ruthless Predator (W) stun breaks her combo, and Slice and Dice (E) dash superiority snowballs the early game before level 5.

The Shield Vault (W) leap stun cuts off her engage, and early Comet Spear (Q) poke and burst dominate the lane.

Apprehend (E) pull stops her dive, and Hemorrhage (P) bleed stacks plus a Noxian Guillotine (R) execute punish her all-in.

Realm of Death (R) isolates her 1v1, then Indestructible (W) shield and heal outlast her to turn the duel around.