Sion's charge-up Decimating Smash (Q) is easily dodged with Twitch's Ambush (Q) stealth, and Twitch kites away while melting the tanky Sion with Deadly Venom (P) damage over time.

Against squishy Nidalee, Twitch uses Ambush (Q) stealth to close in and ignore Javelin Toss (Q) range, then out-trades her Aspect of the Cougar (R) melee form with Deadly Venom (P) damage over time.

Twitch is squishy with a weak early duel, so once Nunu sticks with Biggest Snowball Ever! (W) knockback and slow, he bursts Twitch down with Consume (Q) true damage.

Tantrum (E) reduces Twitch's auto-attack damage so he can't break Amumu's tankiness, and after a Bandage Toss (Q) hit he melts under Despair (W) %HP damage during the Curse of the Sad Mummy (R) stun. Twitch has no self-peel CC or mobility to stop the melee engage.

Rengar leaps from brush with Unseen Predator (P) and Thrill of the Hunt (R) to instantly kill squishy Twitch, and uses empowered Savagery (Q) plus stealth detection to turn Twitch's Ambush (Q) against him.

Kha'Zix bursts down an isolated Twitch in a jungle 1v1 with the isolation-empowered Taste Their Fear (Q), and uses Leap (E) to close the gap on Twitch's Ambush (Q) stealth.

Master Yi becomes untargetable with Alpha Strike (Q) to dodge Twitch's Deadly Venom (P) damage over time, and wins the DPS race with Meditate (W) healing and attack speed.