Poke with Tides of Blood (E) to disrupt Nasus's last-hit stacking on Siphoning Strike (Q), then kite the melee Nasus while sustaining with Transfusion (Q) to seize lane control.

Dodge Volibear's Frenzied Maul (W) burst while untargetable with Sanguine Pool (W), then create distance and kite with Tides of Blood (E), holding the edge in late-game carry potential.

Before level 5, pin the melee Kayle to lane with Tides of Blood (E) poke to deny CS, and overwhelm her with a Hemoplague (R) damage-amp all-in before she scales.

Pressure the item-starved early Vladimir with Blood Hunt (W) attack-speed autos and lifesteal damage, and whenever the long-cooldown Sanguine Pool (W) is down, take the edge with an Infinite Duress (R) all-in.

Though outranged, Sett pressures the weak-early Vladimir with Knuckle Down (Q) gap-close and Facebreaker (E) grab all-ins, ignoring his sustain with the true damage from the center of Haymaker (W).

An empowered Ruthless Predator (W) stun and the double dash of Slice and Dice (E) all-in collapse Vladimir's weak early laning before his lifesteal comes online.

Darius's outer-blade heal from Decimate (Q), the pull of Apprehend (E), and stacking Hemorrhage (P) bleed put Vladimir behind in early trades, and even Sanguine Pool (W) can't stop the Noxian Guillotine (R) execute.

Aegis Assault (E) blocks autos and Tides of Blood (E) poke, and the guaranteed Shield Vault (W) stun plus Comet Spear (Q) poke melt the weak-early Vladimir in an instant.