Zilean's double-stacked Time Bomb (Q) poke wears down the immobile Sona, whose Aria of Perseverance (W) heal alone can't keep up, so she cedes lane priority.

Milio has no hard CC to pin Zilean, Time Bomb (Q) poke outpaces the healing from Cozy Campfire (W) and Warm Hugs (E), and Time Warp (E) speed slips away from Breath of Life (R) engages.

Zilean's double-stacked Time Bomb (Q) burst outraces Soraka's single-target Astral Infusion (W) heal to pressure her health, and she has no kill threat to trade back.

pre-5 Yuumi's You and Me! (W) attach offers little, so Zilean freely poke with Time Bomb (Q) and dodge the Yuumi-carry all-in with Time Warp (E) speed.

Leona's Zenith Blade (E) into Shield of Daybreak (Q) lockdown catches Zilean before he can react with Time Warp (E) speed or Time Bomb (Q), bursting him down, and Solar Flare (R) re-CCs through the Chronoshift (R) revive.

Caught by Blitzcrank's Rocket Grab (Q), the squishy Zilean is yanked out of position into Power Fist (E) knockup and deleted, with no window to land a Time Bomb (Q) stun.

Pyke's Bone Skewer (Q) pull into Phantom Undertow (E) stun into Death From Below (R) chain punishes the squishy Zilean, and Ghostwater Dive (W) roams plus vision control steal priority.

Nautilus chains Dredge Line (Q) pull, Staggering Blow (P) root, and Depth Charge (R) airborne to keep Zilean locked down and burst him.

Brand out-pokes Zilean with the higher burst of Sear (Q), Pillar of Flame (W), and Conflagration (E), and Zilean lacks the sustain to weather that harass.