When Safe lane poke that chips the enemy's health while self-healing off Q

1. QSaw poke→
2. EEmpower→
3. AutocancelEmpowered attack

Tip Q scales off the target's current health (not missing), so throw it early in a trade. E only applies to a basic attack, so activate it after Q.

When Charge W for the aura, pin the target in range with Q, then recast W to detonate for a large heal

1. WStart charge→
2. QSlow→
3. EEmpower→
4. AutocancelEmpowered attack→
5. WDetonate heal

Tip W's heal scales with damage taken during the charge, so detonate near the end of the 4-second window to maximize it. Keep the target pinned in range with Q's slow.

When Activating R before committing the full W-Q-E rotation

1. RR engage→
2. WStart charge→
3. QSlow→
4. EEmpower→
5. AutocancelEmpowered attack→
6. WDetonate finish

Tip R restores more when Dr. Mundo has already lost health, but casting it too late can get Dr. Mundo killed before the healing arrives. Activate it just before committing or after taking a large hit, then let W store incoming damage and detonate on a champion or large monster to convert it back into health.

When Charging W for the full 4 seconds, using R to survive at low health, then detonating W for maximum healing

1. WStart charge→
2. EEmpower→
3. AutocancelEmpowered attack→
4. QSlow hold→
5. AutocancelBasic attack weave→
6. RR survive→
7. WMax detonate

Tip E has a 6.5–8-second cooldown, so Dr. Mundo cannot empower twice in one combo. Use the empowered basic attack once, then weave normal basic attacks and Q slows to hold W range and delay the detonation to maximize the heal.