Void Stone (P) sharply cuts Ryze's Overload (Q) magic poke, Null Sphere (Q)'s shield absorbs the combo, and its silence breaks up Rune Prison (W) follow-up. Riftwalk (R) gives the late-game edge.

All of Vladimir's damage is magic, so Void Stone (P)'s magic reduction neutralizes trades and Null Sphere (Q)'s shield absorbs the Hemoplague (R) burst. Late-game scaling edge.

Void Stone (P) chips away Swain's sustained magic damage and Null Sphere (Q)'s shield absorbs Death's Hand (Q) drain. Riftwalk (R) lets Kassadin harass from outside Nevermove (E)'s range.

While Kayle is helpless as a melee, short-range champion at levels 1-5, Kassadin repeatedly all-ins with Riftwalk (R) initiations, crushing her before she scales.

Exploiting Kassadin's vulnerability before level 5, Diana bursts him down with the Crescent Strike (Q)-Lunar Rush (E)-Moonfall (R) chain, taking control before his power spike.

From level 1, Renekton's Ruthless Predator (W) stun and Slice and Dice (E) physical all-in render Void Stone (P)'s magic reduction meaningless and dominate the weak early Kassadin.

Shield Vault (W)'s leap stun and Comet Spear (Q) poke deal physical damage that bypasses Null Sphere (Q)'s shield, seizing full control before level 5.

Apprehend (E)'s pull and Hemorrhage (P)'s physical damage overpower melee trades, and the Noxian Guillotine (R) execute finishes Kassadin before he scales.

Blinding Dart (Q) shuts down his autos and ranged harass kites him, making it impossible for melee Kassadin to even close the gap.