Ranged Overload (Q) poke and Rune Prison (W) roots disrupt Nasus's Siphoning Strike (Q) stacking and push the wave, overwhelming his CS and health before he scales.

With no mobility Sion gets kited endlessly by Overload (Q) and Spell Flux (E) poke, and his slow-charging Decimating Smash (Q) knock-up is sidestepped so he lands no combo.

His magic damage makes armor-focused stats useless, and sustained Overload (Q) and Spell Flux (E) poke that outpaces Granite Shield (P) steadily chips Malphite's early health.

As a melee carry before level 5, Kayle gets pushed in by ranged Overload (Q) poke and starved of CS, shutting down her late-game scaling entirely.

With no mobility Ornn eats constant Overload (Q) poke and gets safely harassed from outside his short-range Searing Charge (E) knock-up.

Wind Wall (W) blocks Overload (Q)'s projectile, but it does not stop Rune Prison (W)'s targeted root. After denying Q, Yasuo uses Sweeping Blade (E) to force a short melee trade.

He closes instantly with Living Shadow (W) dashes to burst, and Death Mark (R) kills Ryze before he can complete his Rune Prison (W) combo.

Fizz dodges Rune Prison (W) roots and Overload (Q) with Playful/Trickster (E) untargetability, then dives in to unload burst.

Early Ruthless Predator (W) stuns and Slice and Dice (E) double dashes interrupt Ryze's combo, and short-cooldown all-ins keep Renekton ahead in lane.

She resets on minions with Bladesurge (Q) to close the gap and interrupts Ryze's Rune Prison (W) root combo with Flawless Duet (E) stun to land her all-in.