Yasuo's Wind Wall (W) can't block the ground-based AoE Obliterate (Q); Indestructible (W) tanks the burst from his Sweeping Blade (E) dash, then Realm of Death (R) isolates him and cuts off his escape.

Realm of Death (R) isolates Yone and shuts down the rewind escape of Soul Unbound (E), while the AoE Obliterate (Q) and the health built from Indestructible (W) crush him with no room to kite.

Indestructible (W)'s shield absorbs the combo burst from Living Shadow (W), and Realm of Death (R) isolates Zed, neutralizing the repositioning and escape of Death Mark (R).

Kassadin's melee laning before level 5 is extremely weak, so pulling him in with Death's Grasp (E) and hammering him with Obliterate (Q) breaks him before he scales.

Kayle has no range or damage before scaling, leaving her vulnerable to an early all-in that hooks with Death's Grasp (E) into Obliterate (Q); her lane collapses before her scaling comes online.

Blinding Dart (Q) shuts off the empowered autos and damage-over-time of Darkness Rise (P), and against his ranged poke the short range of Death's Grasp (E) makes it hard to even close in.

Sanguine Pool (W) makes him untargetable to dodge the pull of Death's Grasp (E) and the cast of Realm of Death (R); his lifesteal sustain outlasts the lane and turns it around late.

Riposte (W) parries Obliterate (Q) and Realm of Death (R) to stun, and the true damage from Duelist's Dance (P) vitals ignores the health built from Indestructible (W), winning the 1v1 inside Realm of Death (R).

Jayce chunks Mordekaiser's health with the ranged poke of Shock Blast (Q) in Mercury Cannon (R) form before he can close, and with only Death's Grasp (E) to engage he gets kited endlessly.

While Gwen is inside Hallowed Mist (W) and Mordekaiser remains outside, Realm of Death (R) cannot target her and Death's Grasp (E) cannot affect her. Mordekaiser can attack after entering the mist, so Gwen must control spacing around its edge with Skip 'n Slash (E).