Twitch is weak early with no mobility, so before Deadly Venom (P) stacks pile up, Nilah engages and all-ins; even popping Ambush (Q) stealth, he loses the lifesteal brawl against Jubilant Veil (W).

Both are melee hypercarries, but Vayne is weak early, so Nilah uses Jubilant Veil (W) to shrug off Condemn (E) and autos, winning the early skirmish first and snowballing.

In a brawl, Nilah's Jubilant Veil (W) negates Samira's autos and combos, and her lifesteal sustain wins prolonged fights, cutting off Daredevil Impulse (P) stacking.

Nilah is melee-range, so Miss Fortune chips her health before she closes in with Double Up (Q) poke and Love Tap (P), making it hard for Nilah to stick.

Nilah is melee and must step up to farm CS, but a Kog'Maw with Bio-Arcane Barrage (W) active keeps poking with extended-range autos and Living Artillery (R), denying lane access outright.

Caitlyn zones melee Nilah with 650 range plus Yordle Snap Trap (W) and Headshot (P) poke before she can close, pushing the lane and building zone control; when Nilah's Jubilant Veil (W) is on cooldown she gets whittled down helplessly.

Ashe's permanent slows from Frost Shot (P) autos and Volley (W) completely shut down Nilah's approach for endless kiting, and the moment Nilah engages with Apotheosis (R) she cuts it off with Enchanted Crystal Arrow (R).

Varus's long-range Piercing Arrow (Q) poke and Blighted Quiver (W) stacks chip Nilah's health before she can approach, taking the lane advantage before she can open a melee all-in angle.