Condemn (E) can knock Samira out of Wild Rush (E)'s engage or interrupt Inferno Trigger (R)'s channel. Because Blade Whirl (W) can block Condemn, Vayne should wait for it to end before spacing with Tumble (Q) and Silver Bolts (W).

When Kai'Sa closes with Killer Instinct (R), Condemn (E) knocks her away and slows Plasma stacking. During Final Hour (R), Tumble (Q)'s invisibility breaks the follow-up basic attacks after Icathian Rain (Q), giving Vayne room to complete Silver Bolts (W) first.

Vayne is also short-ranged and weak early, so Twitch's stealth ambush closes the gap past her Condemn (E) and wins early trades with poison burst.

Vayne's short auto range gets poked from outside Super Scorcher Breath (Q), and she can't contest Dragon Practice stacking before level (P)3, letting Smolder scale comfortably.

Lucian's Lightslinger double-shot passive and E dash harass punish short-range Vayne throughout the early game and win all-ins.

Vayne is short-ranged with no poke, so Kog'Maw out-ranges her with attack range steroid (W) and harasses her farm with long-range R.

Vayne's 550 range is short and her early damage is weak, so Jinx uses the extended AoE range of Switcheroo (Q)! rocket mode to poke constantly and pressure the lane safely.