When Safe-range harass and trades without overcommitting mana

1. EApply Flux→
2. QEmpowered

Tip Apply Flux with E first, then Q consumes it for bonus damage and bounces to nearby Fluxed enemies. Ryze can spread E through a minion wave toward a champion, but Q stops on the first target, so fire only when the line is open.

When Lock the enemy with a root and win a trade when they step up

1. EApply Flux→
2. WRoot→
3. QEmpowered

Tip W only slows an unmarked target; against a Fluxed target it consumes the mark to root. Use E-W to stop movement, immediately land the Q refreshed by W, then use the movement speed from discharging two runes to create distance.

When All-in or teamfight: chain Overload resets for maximum burst

1. EApply Flux→
2. QFirst empowered hit→
3. WRoot→
4. QSecond empowered hit→
5. ESpread Flux→
6. QThird empowered hit

Tip Both E and W refresh Q, so use E-Q-W-Q-E-Q and fire one Q after each reset. The Q that discharges two runes also grants movement speed, but a minion blocking Q cuts much of the sequence's damage, so clear the line to the target first.

When Flank or reposition through the portal, then burst someone down

1. RPortal→
2. EApply Flux→
3. QFirst empowered hit→
4. WRoot→
5. QSecond empowered hit

Tip Realm Warp activates after 2 seconds, so the portal has to be placed before the flank is needed. R's passive also raises Overload's bonus damage against Flux-marked targets to as much as 50%.