Poke with Overload (Q) and lock him down with Rune Prison (W) to push Nasus off the lane, disrupting his Siphoning Strike stacking and pressuring his CS from early on.

Before level 5 and her items, Kayle is a vulnerable melee, so Ryze pins her with Rune Prison (W) and dominates the lane with sustained Overload (Q) damage.

Absorb Malphite's Seismic Shard (Q) poke with shields and win trades through sustained Overload (Q) and Spell Flux (E) damage to seize lane control.

Pressure Veigar before he stacks Baleful Strike (Q), and when he misses Event Horizon (E), bind him with Rune Prison (W) and all-in.

Zed dodges Rune Prison (W) with the mobility of Living Shadow (W) and Shadow Slash (E), then bursts Ryze down with Death Mark (R) before he can land his combo.

Fizz uses the untargetable window of Playful / Playful / Trickster (E) to dodge Rune Prison (W) and Overload (Q), then melts Ryze with a Chum the Waters (R) all-in.

Akali makes Rune Prison (W) whiff with the invisibility of Twilight Shroud (W) and the evasive dash of Shuriken Flip (E), then kills Ryze with a Perfect Execution (R) assassination combo.

Wind Wall (W) blocks Overload (Q)'s projectile, but it does not stop Rune Prison (W)'s targeted root. Yasuo can deny Q and use Sweeping Blade (E) to repeat short trades.

With Rake (W), leaping burst from Assassin's Path (E), and roam pressure, Talon cuts down the immobile Ryze before he can scale.