Nasus is a melee champion with no early gap-closer, so Seraphine uses her long-range High Note (Q) to disrupt his Siphoning Strike (Q) stack farming and pokes with Beat Drop (E), pushing the lane to apply constant pressure.

Early Kayle is melee-ranged and very vulnerable, so Seraphine uses High Note (Q) poke to push her out of lane and stunt her growth before she gains range and her level-6 power spike with Divine Judgment (R).

Ryze has no early mobility and his Overload (Q) is short-range, so Seraphine pokes with her range advantage, engages with Beat Drop (E), and wins prolonged standoffs with Surround Sound (W) healing.

Aurelion Sol is weak early and has no mobility, so Seraphine uses her long-range High Note (Q) to disrupt his Breath of Light (Q) stack growth and seizes lane priority to slow his scaling.

Zed uses Living Shadow (W) to dodge Seraphine's skillshots and bursts her down so fast with Death Mark (R) that her Surround Sound (W) shield is meaningless; with no mobility, Seraphine has no way to escape.

Fizz's Playful/Trickster (E) untargetability shrugs off Seraphine's Beat Drop (E) root and Encore (R), then he all-ins for burst; with no evasion, Seraphine gets deleted.

Akali's Twilight Shroud (W) smoke negates Seraphine's CC and poke, and she closes in with Shuriken Flip (E) and Perfect Execution (R) dashes to instantly cut down the immobile Seraphine.

Katarina dodges Seraphine's skillshots with minion and Shunpo (E) dashes and snowballs off Death Lotus (R) execution resets, easily sticking to the mobility-less Seraphine.

Kassadin repeatedly re-engages with Riftwalk (R), shrugs off Seraphine's poke with Null Sphere (Q)'s magic shield, and hard outscales to overwhelm her late.