Kindred is a squishy with low early armor, so Talon's Noxian Diplomacy (Q) gap-close plus Rake (W) bleed combo deletes it before Lamb's Respite (R) is available.

Before level 5 Evelynn lacks Demon Shade (P) camouflage and has weak clear and dueling, so Talon dominates early invades and skirmishes one-sidedly.

Before transforming, Kayn is weak in duels until his Darkin Scythe (P) form completes, so Talon bursts him down first with Noxian Diplomacy (Q).

Twitch is squishy and weak early, so Talon melts him with Noxian Diplomacy (Q) burst before his Spray and Pray (R) DPS ramps up.

When Talon closes the gap over walls with Assassin's Path (E), a squishy Nidalee stuck in Aspect of the Cougar (R) melee form dies to the Rake (W) + Noxian Diplomacy (Q) burst before she can kite.

Warwick survives the burst with Jaws of the Beast (Q) lifesteal sustain and pins Talon down with Infinite Duress (R) suppression to kill him back.

Rammus's Defensive Ball Curl (W) reflects and reduces physical damage, so Talon's physical burst can't take down the tank.

Xin Zhao out-duels squishy Talon early with the Three Talon Strike (Q) third-hit knock-up and Determination (P) healing sustain, and once he sticks with Audacious Charge (E) Talon can't escape.

Vi's Vault Breaker (Q) dash and Cease and Desist (R) lockdown catch mobile Talon with guaranteed CC, and her tankiness soaks the burst.

Nocturne's Shroud of Darkness (W) spellshield blocks Talon's engage, and he wins the duel by disabling Talon with Paranoia (R) vision denial and Unspeakable Horror (E) fear.