Lacking any dash, Nasus can't build Siphoning Strike (Q) stacks against Tumble (Q) kiting, and Silver Bolts (W) deals max-health true damage that ignores his high armor entirely.

Silver Bolts (W) deals max-health true damage that melts Mundo's health stacking, and Tumble (Q) dodges Infected Bonesaw (Q) to neutralize his engage.

Unstoppable Onslaught (R) is unstoppable and cannot be interrupted mid-charge by Condemn (E). Vayne must read its path and sidestep with Tumble (Q), then create distance with Condemn after the charge ends and stack Silver Bolts (W)'s max-health true damage.

Sett has no dash, leaving him vulnerable to Tumble (Q) kiting, and Condemn (E)'s knockback repels Facebreaker (E)'s pull and approach to shut down melee entirely.

Darius has no dash, so he's endlessly kited by Tumble (Q), and Condemn (E)'s knockback breaks his Apprehend (E) pull combo.

Blinding Dart (Q) seals Vayne's autos to zero out her damage, and Toxic Shot (P) poison harass pushes the lane before she can close in.

Wind Wall (W) blocks both her autos and Condemn (E), completely nullifying Vayne's damage and CC.

Shield Vault (W) is a targeted stun that Tumble (Q) cannot simply sidestep. An empowered W into Comet Spear (Q) lets Pantheon control the early exchange before Vayne can create distance.

Slice and Dice (E)'s double dash closes instantly and Ruthless Predator (W)'s stun breaks her kiting, melting the squishy Vayne with early burst.

Ragnarok (R) ignores all CC and slows so Condemn (E) and kiting fail, and Undertow (Q)'s slow plus lifesteal keeps him glued to her to the end.