Weave through Noxious Trap (R) with the Lacerate (E) dash, and since your damage rides on abilities you can still burst-combo an all-in even while blinded by Blinding Dart (Q).

Dodge the Apprehend (E) pull with the Lacerate (E) dash and the mobility-less Darius has no way to fight back; soak the Decimate (Q) and pull combo with Repudiation (W), then stick on him for the all-in.

Drakehound's Step (P) lets Ambessa dash away from Haymaker (W)'s center and Facebreaker (E)'s frontal angle. From the flank, Lacerate (E)'s slow and Cunning Sweep (Q)'s outer-edge damage are difficult for immobile Sett to answer.

With no mobility or CC he is defenseless against pre-5 Lacerate (E) dash-combo all-ins, can't stack Siphoning Strike (Q), and gets crushed in lane.

She has no mobility and her early melee form is extremely weak, so you repeatedly kill her with Lacerate (E) dash all-ins before she scales into her ranged form.

She dodges your dash combo with Tumble (Q) and breaks the clinch with the Condemn (E) knockback, kiting at range so you never get a damage window.

He shoves with long-range Shock Blast (Q) poke and, when you close in, peels you off with the Thundering Blow (E) knockback, stealing lane priority.

Shield Vault (W)'s targeted stun immediately stops Ambessa's dash chain. Pantheon blocks her frontal burst with Aegis Assault (E) and controls early trades with Comet Spear (Q).

Steadfast Presence (W) flat-out negates your Lacerate (E) dash and shuts down your engage combo, then she punishes back with the Heroic Charge (E) wall-stun.