Kassadin has no mobility until Riftwalk (R), leaving him extremely weak early; Annie pressures the lane with Disintegrate (Q) poke and all-ins with a full Pyromania (P) 4-stack stun to cut him down before his ultimate comes online.

Ryze has no dash, so he gets caught by Annie's point-and-click Pyromania (P) 4-stack stun and bursts down to the Incinerate (W) + Disintegrate (Q) + Summon: Tibbers (R) combo.

Vladimir is weak in the early levels and Sanguine Pool (W) drains his own health, so he fully cedes lane priority before level 5 to Annie's Pyromania (P) stun-burst all-in.

As a melee champion, Nasus can't stack Siphoning Strike (Q) under Annie's Disintegrate (Q) range poke and Summon: Tibbers (R) pressure, and keeps getting pushed in lane.

Malphite is a melee champion with no dash, so Annie's Disintegrate (Q) poke keeps stripping his Granite Shield (P) and he's vulnerable to the Pyromania (P) 4-stack stun all-in.

Zed dodges Summon: Tibbers (R) and Annie's combo with Living Shadow (W) and Death Mark (R), then bursts her down before she can build up the Pyromania (P) stun.

Fizz uses Playful / Trickster (E) to dodge Annie's point-and-click Pyromania (P) stun and combo, then all-ins to delete her.

Zoe pokes one-sidedly from beyond Annie's short range with Sleepy Trouble Bubble (E) sleep and long-range Paddle Star! (Q).

Talon pressures Annie's short range with Rake (W) poke and Assassin's Path (E) wall-hopping mobility, then cuts her down with instant burst.

Twisted Fate overwhelms Annie's short range with Wild Cards (Q) poke, the Pick a Card (W) gold-card stun, and Destiny (R) roams, outpacing her in influence beyond the lane.