Draven has no reliable escape, so even his all-ins get slipped by Ezreal's Arcane Shift (E). While he moves to catch his Spinning Axe (Q), Ezreal pokes with Mystic Shot (Q) and breaks his axe rhythm.

Twitch is short-ranged, so Ezreal chips him with Mystic Shot (Q) before he can drop Ambush (Q) stealth and close in. Even when he sticks for Contaminate (E) burst, Ezreal escapes with Arcane Shift (E).

Kog'Maw has no mobility and is fully exposed to Mystic Shot (Q) poke. Ezreal keeps pushing him around in lane before his Bio-Arcane Barrage (W) scaling comes online.

Nilah is melee-ranged, so Ezreal kites with Arcane Shift (E) and pokes with Mystic Shot (Q), making it hard for her to even close the gap. Even when she dashes in with Slipstream (E), Ezreal re-opens the distance with his own E.

Miss Fortune grinds Ezreal down with Love Tap (P) and the Double Up (Q) bounce, so a passive Mystic Shot (Q)-reliant Ezreal keeps losing the lane trades.

Caitlyn outranges Ezreal, poking from beyond his auto range with Piltover Peacemaker (Q) and Headshot (P), and punishes his Arcane Shift (E) landing spot with a Yordle Snap Trap (W).

Varus out-pokes Ezreal with the long range of Piercing Arrow (Q) and wins trades by detonating Blighted Quiver (W) stacks for burst.

Lucian overpowers Ezreal in early skirmishes with Lightslinger (P) double shots and the Relentless Pursuit (E) dash, and his Piercing Light (Q) combo all-in burst is strong.