Inspire (E) empowered by Mantra (P) gives shield and movement speed to shrug off Nautilus's Dredge Line (Q) hook and dodge his approach, while Inner Flame (Q) poke chips his HP before he engages, erasing his all-in window.

Inner Flame (Q) poke outranges and out-bursts Soraka, and Focused Resolve (W)'s snare cuts off her Starcall (Q) harass timing, securing the lane lead.

Inspire (E) empowered by Mantra (P) provides shield and speed to slip out of Rocket Grab (Q) range, while Mantra (P)-empowered Inner Flame (Q) poke keeps chipping the advancing Blitzcrank to pressure the lane.

The moment Yuumi latches on, Inner Flame (Q) poke harasses both the carry and Yuumi, and Inspire (E)'s shield and movement speed neutralize Yuumi's Prowling Projectile (Q) harass to seize lane control.

Early Sona is short-ranged and squishy, so she keeps eating Karma's long Inner Flame (Q) poke, and once caught by Focused Resolve (W)'s snare she has no escape.

Pyke's Bone Skewer (Q) pull and all-in easily catch the mobility-less Karma, and she is also vulnerable to Death From Below (R)'s execute range.

Leona's Zenith Blade (E) dash and Shield of Daybreak (Q) stun hard-CC lock Karma down before she can use Inspire (E)'s shield and movement speed, losing the trade.

Caught by Thresh's Death Sentence (Q) hook, the mobility-less Karma gets dragged in and loses lane control.