When melee Nasus steps up to stack Siphoning Strike (Q), Karma pokes relentlessly with Inner Flame (Q) to whittle his health and disrupt his last-hitting and farm.

Before Kassadin picks up Riftwalk (R) at level 5, his mana shortage and short range leave him vulnerable, letting Karma dominate the lane with Inner Flame (Q) poke amplified by Mantra (P).

Karma absorbs the burst from Death Lotus (R) with the Inspire (E) shield, and cuts the channel with the Focused Resolve (W) root to neutralize Katarina's ultimate damage.

When melee Yone tries to close in, Karma kites with the Inspire (E) move speed, and tanks the third-hit knock-up all-in from Mortal Steel (Q) with her shield.

Zed swaps position with Living Shadow (W) to dodge Karma's Inner Flame (Q) and Focused Resolve (W) skillshots, then the burst from Death Mark (R) breaks through her single shield for the kill.

Fizz blinks untargetable with Playful/Trickster (E) to evade Inner Flame (Q) and the Focused Resolve (W) root, then dives straight in to unload burst.

Akali breaks vision with the Twilight Shroud (W) stealth to nullify Karma's Inner Flame (Q) poke, then all-ins with high mobility to burst through the shield.

Ahri uses the mobility of Spirit Rush (R) to dodge the Inner Flame (Q) and Focused Resolve (W) skillshots, sets up all-ins and ganks with Charm (E), and holds the edge in roaming pressure as well.