Veigar has no mobility, so Kayle safely pokes one-sidedly with Radiant Blast (Q); she nullifies the burst of Primordial Burst (R) with the invulnerability of Divine Judgment (R) and overwhelms him with late-game sustained DPS.

Nasus has no ranged poke at all, so Kayle farms and harasses one-sidedly with Radiant Blast (Q), seizing full lane priority before Nasus stacks Siphoning Strike (Q), and out-scales him as well.

Kassadin has no all-in before Riftwalk (R) at level 5 and Force Pulse (E) has short range, so Kayle kites and pokes throughout the laning phase with Radiant Blast (Q), taking full early priority.

Kayle is melee-ranged early and very weak before she comes online, while Aurelion Sol keeps pushing with the continuous poke of Breath of Light (Q) and dominates the lane before level 5.

Zed pressures the weak early Kayle with Razor Shuriken (Q) and Shadow Slash (E), then tries to kill her before she scales with a Death Mark (R) all-in after level 5; even surviving with the invulnerability of Divine Judgment (R), she loses lane priority entirely.

Talon repeatedly kills Kayle from early on with Noxian Diplomacy (Q) melee all-ins and Assassin's Path (E) wall-hopping roams, opening a gap before Kayle reaches her scaling.

Katarina bursts down the weak early-to-mid Kayle with Bouncing Blade (Q) and Death Lotus (R), and collapses the lane through the Voracity (P) reset on kills.

Fizz uses Playful/Trickster (E)'s untargetable state to dodge Radiant Blast (Q), then repeats short all-ins against Kayle's weak early defenses. Kayle must keep more conservative spacing until Divine Judgment (R).