Before level 5 Kassadin has no gap-closer, so Orianna zones him with Command: Attack (Q) poke and the Command: Dissonance (W) slow field, stunting his scaling.

Melee Nasus gets pushed off farm by Orianna's ball-carried Command: Attack (Q) poke, missing last hits and Siphoning Strike (Q) stacks; when he engages she answers with the Command: Protect (E) shield and Command: Shockwave (R).

When Katarina opens with Shunpo (E) and Bouncing Blade (Q), Command: Shockwave (R) instantly interrupts and denies Death Lotus (R), while the Command: Protect (E) shield absorbs her burst and zoning blocks her resets.

Melee Malphite has no way to contest Orianna's Command: Attack (Q) and Command: Dissonance (W) poke before level 5, bleeding health on the lane.

Zed uses Living Shadow (W) to juke Orianna's ball placement, and Death Mark (R) burst blows through the Command: Protect (E) shield to delete her.

Fizz gains untargetability with Playful / Trickster (E) to dodge Command: Shockwave (R), then dives in and bursts Orianna down.

Akali hides from ball-targeting inside the Twilight Shroud (W), then closes with Shuriken Flip (E) and Perfect Execution (R) mobility to melt Orianna.

Talon pressures with Rake (W) poke and Assassin's Path (E) wall-hops for all-ins and roams, and Shadow Assault (R) stealth lands burst that makes the Command: Protect (E) shield irrelevant.

Irelia dashes in with Bladesurge (Q) across minions and champions, blocks poke with Defiant Dance (W), and grinds down the Command: Protect (E) shield with sustained damage to pressure the lane.