Close the gap with the double dash of Slice and Dice (E) and lock him down with an empowered Ruthless Predator (W) stun, shutting off Siphoning Strike (Q) stack farming and pressuring the lane.

Kayle has no defensive tools before level 5, so approach with Slice and Dice (E), then repeatedly execute her with empowered Ruthless Predator (W) stun all-ins to snowball.

Kassadin has no early poke or escape, so keep pressuring him with Slice and Dice (E) dash engages and empowered Ruthless Predator (W) stuns to deny his farm outright.

Early Vladimir is squishy before his ultimate, so crush him with empowered Ruthless Predator (W) stun all-ins to shut down his Transfusion (Q) healing.

Hallowed Mist (W) has a long cooldown early. Once it is down, Renekton can close with Slice and Dice (E), chain an empowered Ruthless Predator (W) stun into Cull the Meek (Q), and control the lane before Gwen completes her core items.

Riposte (W) parries and negates the empowered Ruthless Predator (W) stun and reflects it back, and vital damage from Lunge (Q) and Duelist's Dance (P) turns the duel around.

Counter Strike (E) dodges the empowered Ruthless Predator (W) auto and stuns him back to break the all-in, then Jax overwhelms in extended late-game trades laced with Leap Strike (Q).

Granite Shield (P) and high armor neutralize Renekton's AD burst, making trades pointless.

Kites with ranged autos and Boomerang Throw (Q), then after transforming into Mega Gnar reverses Renekton's all-in with the GNAR! (R) knockback.

Blinding Dart (Q) cuts off Renekton's empowered autos and the fury generation of Reign of Anger (P), while ranged Toxic Shot (P) poke denies him the ability to close in.