A Thousand Cuts (P)'s max-health magic damage punishes Nasus's health-focused scaling. When Nasus is outside Hallowed Mist (W), he cannot target Gwen and cannot immediately land a Siphoning Strike (Q)-empowered attack.

A Thousand Cuts (P)'s max-health magic damage and Snip Snip! (Q)'s center damage punish Mundo's health-focused defenses. While Mundo remains outside Hallowed Mist (W), Infected Bonesaw (Q) cannot affect Gwen, letting her control spacing around the mist's edge.

Her damage is primarily magic, so it pierces straight through Malphite's armor-focused build, and %max-HP damage renders his armor stacking meaningless.

A Thousand Cuts (P)'s max-health magic damage punishes Sion's health-focused defenses. While Gwen is inside Hallowed Mist (W) and Sion remains outside, Unstoppable Onslaught (R) and Decimating Smash (Q) cannot affect her, giving Gwen control over the fight's position.

A Thousand Cuts (P)'s max-health magic damage punishes Ornn's high health and defenses. While Ornn remains outside Hallowed Mist (W), Volcanic Rupture (Q) and Call of the Forge God (R) cannot affect Gwen, letting her attack from the mist and adjust spacing with Skip 'n Slash (E).

Riposte (W) Riposte blocks and stuns Gwen's Skip 'n Slash (E) Skip 'n Slash empowered auto and Needlework (R) Needlework needles, while Duelist's Dance (P) Duelist's Dance vital true damage wins the extended duel.

Camille can use Hookshot (E) to enter Hallowed Mist (W) and threaten its stun. Adaptive Defenses (P)'s shield absorbs Gwen's first magic damage, while Precision Protocol (Q)'s second-hit true damage controls short trades.

Blinding Dart (Q) makes Gwen's basic attacks and Skip 'n Slash (E)-empowered attacks miss, but it does not stop the ability damage from Snip Snip! (Q) or A Thousand Cuts (P). Teemo must maintain distance with Toxic Shot (P) poke and Move Quick (W).

Early Ruthless Predator (W) Ruthless Predator stun and Slice and Dice (E) Slice and Dice all-ins empowered by Reign of Anger (P) Reign of Anger crush Gwen in lane before she scales, locking down her growth.

Once Darius enters Hallowed Mist (W), Apprehend (E) can stop Gwen's disengage and let him build Hemorrhage (P) stacks. Decimate (Q)'s outer-edge healing sustains the extended fight, while Noxian Guillotine (R) creates execute pressure before Gwen scales.