Samira must close in for melee combos, but Senna's long-range autos, Piercing Darkness (Q) poke, and the Last Embrace (W) root cut off her approach and keep her from building Daredevil Impulse (P) combo rank.

Nilah has very short range, so before she can close she gets chipped by Senna's Piercing Darkness (Q) and long-range autos, and if caught by the Last Embrace (W) root her engage is shut down.

Kog'Maw has short early range and no mobility, so Senna uses her range advantage to poke freely with Piercing Darkness (Q) and autos, pressuring the lane.

Vayne has short early range and a weak laning phase, so Senna presses with her range and keeps up steady poke using autos and Piercing Darkness (Q).

Smolder is weak early before stacking Dragon Practice (P), so Senna uses her range advantage to poke with Piercing Darkness (Q) and stunt his scaling.

Caitlyn has the longest range in the game, poking one-sidedly from outside Senna's autos and Piercing Darkness (Q) with Piltover Peacemaker (Q), Headshot (P), and Yordle Snap Trap (W).

Draven's Spinning Axe (Q) gives strong early damage, overpowering low-attack-speed, low-base-damage Senna in lane and winning trades and all-ins.

Lucian uses his Relentless Pursuit (E) dash and Lightslinger (P) burst to dive Senna's slow attack speed, gaining an edge in every short trade.

Miss Fortune's Love Tap (P) and Make It Rain (E) poke overpower Senna's low sustained damage, putting her ahead in the poke war.

Jhin's per-shot damage is very high, and with the Deadly Flourish (W) root and his Whisper (P) fourth shot he holds the advantage in the poke war against low-attack-speed Senna.