Roar of the Slayer (E) poke and minion damage disrupt Nasus's Siphoning Strike (Q) stack farming, cementing an early lane lead before he scales.

Decimating Smash (Q)'s knockup is a melee hit that Wind Wall (W) can't block, and Soul Furnace (W)'s shield plus his high health soak Yasuo's burst while pressuring.

Soul Furnace (W)'s shield absorbs Riven's combo burst, and Roar of the Slayer (E)'s slow cuts off her Broken Wings (Q) dash combo for the edge in melee trades.

Before level 5, Kayle has few defensive tools, so Roar of the Slayer (E) poke and Decimating Smash (Q)'s charged area restrict her access to minions. Sion can push the lane and delay her scaling before she gains ranged attacks.

Roar of the Slayer (E) poke chips away at the melee early-game Tryndamere, and Soul Furnace (W)'s shield plus high health endure his crit burst so he can't easily catch Sion out.

Riposte (W)'s parry nullifies Decimating Smash (Q)'s knockup, and Duelist's Dance (P) vital true damage ignores his defensive stats to dominate the duel.

Silver Bolts (W)'s max-health true damage is effective against a health-stacking tank. Vayne can Tumble (Q) out of Decimating Smash (Q)'s area, interrupt the charge with Condemn (E), and keep spacing Sion.

While Sion remains outside Hallowed Mist (W), Roar of the Slayer (E) and Decimating Smash (Q) cannot affect Gwen. A Thousand Cuts (P)'s max-health magic damage and Snip Snip! (Q)'s center damage punish Sion's health-focused defenses.

Mercury Cannon (R) Shock Blast (Q) ranged form-swap poke pummels from outside Roar of the Slayer (E)'s range to dominate the lane.

Sanguine Pool (W) dodges Decimating Smash (Q)'s knockup and combos while untargetable, and Transfusion (Q) lifesteal plus %-health damage overpower Sion in extended fights.