Zed's Living Shadow (W) and Death Mark (R) dashes get Gloomed by Vex's Doom 'n Gloom (P), and the dash itself is interrupted, shutting down his R all-in engage.

Every time Yasuo dashes through minions with Sweeping Blade (E), Doom 'n Gloom (P) punishes him with Gloom, and interrupting the dash stops him from ever starting his Steel Tempest (Q)–Last Breath (R) knockup combo.

Yone's third-hit Mortal Steel (Q) lunge and Soul Unbound (E) dash get Gloomed by Doom 'n Gloom (P), and interrupting them denies his Fate Sealed (R) engage.

Every Shunpo (E) blink gets Gloomed and interrupted by Doom 'n Gloom (P), and Personal Space (W) bursts her the moment she lands, shutting down her Death Lotus (R) damage window.

Akali's Shuriken Flip (E) and Perfect Execution (R) dashes get Gloomed by Doom 'n Gloom (P), and interrupting them stops her from following up her Twilight Shroud (W) stealth all-in, leaving her open to counterattack.

Annie lands a guaranteed AoE stun burst with Summon: Tibbers (R) off her Pyromania (P) stacks with no skillshot to dodge, and Vex, lacking an evasive dash, eats the full combo.

Lux pressures the lane with longer-range Light Binding (Q) roots and Lucent Singularity (E) poke, and the low-mobility Vex struggles to dodge them.

Ziggs pokes from outside her range with Bouncing Bomb (Q) and shoves the lane, keeping constant pressure on Vex, who lacks a reliable gap-closer.

Syndra dominates with longer-range Dark Sphere (Q) poke and a guaranteed Scatter the Weak (E) stun burst, and having no dash, she gives Vex's Doom 'n Gloom (P) nothing to punish.