Before level 5 Kassadin has no Riftwalk (R) and thus no mobility. Jayce boosts Shock Blast (Q) through Acceleration Gate (E) to poke one-sidedly from out of range, whittling his CS and HP to crush the lane.

Ryze is short-ranged with no early escape. Jayce lands Shock Blast (Q) empowered by Acceleration Gate (E) from beyond Ryze's range, poking him one-sidedly.

Melee Malphite must eat Jayce's Shock Blast (Q) while farming, leaving him helpless against the ranged poke until his core items come online.

Veigar has no mobility, so Jayce poke-chunks him from outside Event Horizon (E) range with Shock Blast (Q) boosted by Acceleration Gate (E), disrupting his Phenomenal Evil (P) stacking and growth.

Jayce harasses farm-reliant melee Nasus with Shock Blast (Q) empowered by Acceleration Gate (E), denying his Siphoning Strike (Q) stacks and lane access to stunt his early scaling.

Yasuo's Wind Wall (W) fully blocks Jayce's key damage Shock Blast (Q), nullifying his ranged edge, and Sweeping Blade (E) lets him close in to force melee trades.

Zed dodges Shock Blast (Q) with Living Shadow (W) and Shadow Slash (E) as he closes in, then bursts down the squishy Jayce with a Death Mark (R) combo.

Fizz gains untargetability with Playful/Trickster (E) to dodge Shock Blast (Q), then closes and bursts Jayce down with a Chum the Waters (R) combo.

Irelia closes the gap instantly with Flawless Duet (E) stun and chained Bladesurge (Q) dashes, overwhelming Jayce in sustained melee combat.

Akali dodges Shock Blast (Q) while advancing under Twilight Shroud (W) stealth, then picks off Jayce with a stealth-based all-in.