Cut his dash-ins with Dredge Line Dredge Line (Q) and the Staggering Blow Staggering Blow (P) root, tank the Death Mark Death Mark (R) burst with tank stats, then answer with the Depth Charge Depth Charge (R) knock-up.

Akali cannot be newly targeted while invisible in Twilight Shroud (W), so Nautilus must cast Depth Charge (R) before she enters or wait until she reveals herself. Once she leaves the shroud, Dredge Line (Q) and Staggering Blow (P)'s root chain together, while Nautilus's durability absorbs her burst.

Before level 5 melee Kassadin has no poke or mobility, so a Dredge Line Dredge Line (Q) → Staggering Blow Staggering Blow (P) → Depth Charge Depth Charge (R) all-in denies him even Null Sphere Null Sphere (Q) trades and crushes his lane.

Pre-scaling melee Kayle is extremely weak, so early Dredge Line Dredge Line (Q) poke plus a Staggering Blow Staggering Blow (P) and Depth Charge Depth Charge (R) CC-chain all-in fully seizes lane control.

Pin the mobility-less Nasus down with Dredge Line Dredge Line (Q) and the Riptide Riptide (E) slow to disrupt his early Siphoning Strike Siphoning Strike (Q) stacking, while tank stats ignore his weak early damage to hold control.

The Silver Bolts Silver Bolts (W) %current-health true damage and Condemn Condemn (E)/Tumble Tumble (Q) kiting make tank stats meaningless, and as a ranged champ she stays outside Dredge Line Dredge Line (Q) range so you can't even close in.

Blinding Dart Blinding Dart (Q) shuts down your autos and the Staggering Blow Staggering Blow (P), and ranged poison poke forces a war of attrition beyond Dredge Line Dredge Line (Q) range.

Sanguine Pool Sanguine Pool (W) nullifies Dredge Line Dredge Line (Q) and Depth Charge Depth Charge (R), and lifesteal sustain plus %health poke wins the attrition fight.

Riposte Riposte (W) parries and negates your key Dredge Line Dredge Line (Q) and Depth Charge Depth Charge (R), while vital true damage melts your defensive stats.

Mini-form ranged Boomerang Throw Boomerang Throw (Q) kiting keeps him hard to reach, and constant poke drains your mana so you can never find a Dredge Line Dredge Line (Q) angle.