Until Kassadin learns Riftwalk (R) at level 5, he's a melee with no mobility, so Syndra abuses the range advantage of Dark Sphere (Q) to poke him endlessly and shove the lane.

Ryze has no dash to dodge Syndra's Dark Sphere (Q) poke, and her stun combo—launching a Dark Sphere (Q) with Scatter the Weak (E)—interrupts his combo and suppresses him before he can build stacks.

Mid Nasus is defenseless against ranged magic poke, so he bleeds CS and health to Syndra's Dark Sphere (Q) spam and gets pushed off the lane.

Malphite has low base magic resist and no mobility besides Unstoppable Force (R), so Syndra rains magic poke with Dark Sphere (Q) from safe range and cuts off his ult charge with Scatter the Weak (E).

Twisted Fate has no laning mobility, so Syndra pressures him with a Dark Sphere (Q) stun launched by Scatter the Weak (E) and Dark Sphere (Q) poke, taking a health lead before Destiny (R) comes online.

Zed slips Syndra's Dark Sphere (Q) and Scatter the Weak (E) skillshots with Living Shadow (W) and his dashes, then deletes the mobility-less Syndra with Death Mark (R).

Wind Wall (W) can stop spheres pushed by Scatter the Weak (E) and the spheres from Unleashed Power (R), but it cannot prevent Dark Sphere (Q) from appearing on the ground. Yasuo should deny the stun and ultimate path before closing in.

Fizz dodges Syndra's Scatter the Weak (E) stun and Unleashed Power (R) with the untargetable window of Playful / Trickster (E), then bursts her down with a melee all-in.

Akali closes in through Syndra's Dark Sphere (Q) poke and Scatter the Weak (E) skillshots with Twilight Shroud (W) and dashes, then removes the mobility-less Syndra with an all-in.

Talon pokes with Rake (W) and vaults walls with Assassin's Path (E) to dodge Syndra's skillshots and close in, then bursts her down in an instant.