Nidalee's Javelin Toss (Q) poke is offset by Mundo's delayed self-heal from Heart Zapper (W) and the massive restore of Maximum Dosage (R); even when she dives in with Aspect of the Cougar (R), the slow from Infected Bonesaw (Q) plus Blunt Force Trauma (E) let Mundo turn on the squishy Nidalee.

Even Evelynn's burst chaining Allure (W) charm into Whiplash (E) can't chunk Mundo's vast health down to Last Caress (R) execute range; Maximum Dosage (R) restores it all, and the Infected Bonesaw (Q) slow even denies her escape back into stealth.

Early Twitch has extremely low health, so Mundo sticks on with the Infected Bonesaw (Q) slow and tanks his autos and Deadly Venom through Heart Zapper (W) self-healing, walking him down.

Olaf's Ragnarok (R) grants slow and CC immunity, nullifying Infected Bonesaw (Q) kiting, while the true damage of Reckless Swing (E) ignores Mundo's thick health pool and grinds him down.

Master Yi's Wuju Style (E) true damage pierces Mundo's armor, and Alpha Strike (Q) goes untargetable to shrug off the Infected Bonesaw (Q) slow while chaining reset damage to melt the tank.

Jaws of the Beast (Q) deals max-health damage and heals Warwick for damage dealt, making it effective against high-health Mundo. If Infinite Duress (R)'s aimed suppression lands, Mundo can be focused before Maximum Dosage (R)'s healing takes over.

A Thousand Cuts (P)'s max-health magic damage punishes Mundo's high health. While Mundo remains outside Hallowed Mist (W), Infected Bonesaw (Q) and his basic attacks cannot affect Gwen, forcing him to enter the mist while Gwen controls the spacing.

Rhaast Kayn's Reaping Slash (Q) overwhelms Mundo in extended trades with max-health-based damage and lifesteal, then executes him after going untargetable with Umbral Trespass (R).