Before level 5 Warwick has no Infinite Duress (R), so Lee Sin kites with Sonic Wave (Q) + Resonating Strike (Q) and ward-flash mobility to win the early duel and shut him down before Blood Hunt (W) snowballs.

Before level 5, Evelynn lacks Demon Shade (P)'s camouflage and cannot disengage with Last Caress (R). Allure (W)'s charm is available early but needs time to arm, so Lee Sin can open with Sonic Wave/Resonating Strike (Q) before the mark completes and control the early fight.

Early Master Yi has no escape when Alpha Strike (Q) is down, so Lee Sin dashes in with Sonic Wave (Q) + Resonating Strike (Q), tanks his autos with Safeguard (W) shield, and crushes him in the jungle with preemptive burst.

Pre-transform Kayn has low burst and sustain on Reaping Slash (Q) and Blade's Reach (W), so Lee Sin seizes control of early invades and objectives with Sonic Wave (Q) + Resonating Strike (Q) and kills him before The Darkin Scythe (P) form completes.

before 5 Shyvana has no CC or gank threat, so Lee Sin engages with Sonic Wave (Q) + Resonating Strike (Q), soaks Flame Breath (E) damage with Safeguard (W) shield, and dominates early duels and dives.

Xin Zhao interrupts Lee Sin's abilities with the third-hit knockup of Three Talon Strike (Q) and outlasts him through Determination (P) healing, overpowering the Safeguard (W)-engaging Lee Sin in extended melee.

Olaf goes CC-immune with Ragnarok (R), so Lee Sin's Dragon's Rage (R) knockback does nothing, and he sticks with Undertow (Q) slow to kill Lee Sin using Berserker Rage (P)-boosted autos.

Jax dodges Lee Sin's autos and on-hit burst with Counter Strike (E) and stuns him, then flips the extended duel with Empower (W) and a scaling lead.