Kayle has no mobility or self-peel until Divine Judgment (R) grants invulnerability, so Warwick locks her down with Infinite Duress (R) and all-ins with Blood Hunt (W) attack-speed autos, shutting off her scaling before level 5.

Warwick pressures an item-starved early Vladimir with Blood Hunt (W) attack-speed autos and Eternal Hunger (P) lifesteal sustain, then all-ins with Infinite Duress (R) whenever the long-cooldown Sanguine Pool (W) is down to seize the lead.

Kassadin has no escape until Riftwalk (R) at level 5, so Warwick crushes him early with Infinite Duress (R) suppression and Blood Hunt (W) attack-speed damage.

Blood Hunt (W)'s chase movement speed lets Warwick stick relentlessly to Singed to deny his proxying and kiting, while Infinite Duress (R) suppression neutralizes his Mega Adhesive (W) footwork angles.

Nasus uses Wither (W) to slash Warwick's attack and movement speed, breaking his auto-attack lifesteal sustain and Infinite Duress (R) chase-initiation, then stacks Siphoning Strike (Q) to survive lane and outscale him late.

Blinding Dart (Q) completely shuts off Warwick's auto-attack damage and Eternal Hunger (P) lifesteal, and his ranged poke kites Warwick out before he can even close the gap.

Hemorrhage (P) bleed damage and Noxian Guillotine (R) execution outpace Warwick's healing, while Apprehend (E) and Crippling Strike (W)'s slow cut off his engage angles, leaving him behind in trades.

Fiora negates Infinite Duress (R) with Riposte (W) and counters with its stun, then dominates extended trades with Duelist's Dance (P) vitals and Lunge (Q).

Renekton's Reign of Anger (P)-fueled early burst and Ruthless Predator (W) stun combo overwhelm Warwick in trades before he can scale up with Blood Hunt (W) and items.