Amumu's Bandage Toss (Q) is a straight-line skillshot that Zed easily dodges with Living Shadow (W), and with low early damage and health he gets blown up by the Living Shadow (W) into Death Mark (R) burst.

Twitch is squishy, so before his Deadly Venom (P) stacks build up Zed deletes him with the Living Shadow (W)-Shadow Slash (E)-Razor Shuriken (Q) combo, cutting him down before he can activate Spray and Pray (R).

Kindred is weak in early melee skirmishes and struggles to kite once closed on, so Zed dives in with Living Shadow (W) for burst, and Lamb's Respite (R) only delays the death.

Master Yi heals with Meditate (W) and dodges Zed's abilities untargetable via Alpha Strike (Q), grinding down the squishy Zed in extended fights.

Warwick sustains through trades with Eternal Hunger (P), then suppresses Zed with Infinite Duress (R), preventing a shadow escape before finishing the fight.

Mundo tanks the squishy Zed's burst with the sustained healing from Goes Where He Pleases (P) and Maximum Dosage (R), and out-heals him to flip the trade in his favor.

Volibear survives Zed's short burst with Thundering Smash (Q)'s stun and Frenzied Maul (W)'s healing. Sky Splitter (E) provides a slow and shield rather than a stun, so the key is to catch Zed with Q and continue the fight inside E's area.

Rammus reflects and blocks AD burst with the thorns of Defensive Ball Curl (W) and Frenzying Taunt (E), so the more Zed sticks to him the more he damages himself.