Twitch is squishy with a weak early duel, so Nunu sticks with Biggest Snowball Ever! (W)'s knockback and slow and melts him fast with Consume (Q)'s true damage.

Pre-transform Kayn has weak early health and damage, so Nunu keeps sticking with Biggest Snowball Ever! (W) to force invades and fights and pile up his losses.

Before level 5 Evelynn has weak clear and dueling and is squishy, so Nunu latches on with Biggest Snowball Ever! (W) and uses Consume (Q)'s true damage to invade and crush her before Last Caress (R) comes online.

Early Master Yi is squishy, so Nunu cuts off his Alpha Strike (Q) angles with Biggest Snowball Ever! (W)'s knockback and slow, then wins the pre-5 duel with Consume (Q)'s true damage and healing.

Lee Sin dominates early skirmishes with level 2-3 invades and his Sonic Wave / Resonating Strike (Q) combo before Nunu can grow Biggest Snowball Ever! (W).

Xin Zhao overpowers Nunu in extended duels with Three Talon Strike (Q)'s third-hit knockup, sustained spear damage, and Crescent Guard (R).

Warwick keeps healing even against tanky Nunu with Jaws of the Beast (Q)'s lifesteal, and overwhelms him by interrupting Absolute Zero (R)'s channel with Infinite Duress (R)'s suppression.

Olaf ignores Biggest Snowball Ever! (W)'s slow and knockback CC with Ragnarok (R) and melts tank Nunu with Reckless Swing (E)'s true damage.

Graves overpowers Nunu in early fight damage with point-blank buckshot and End of the Line (Q)'s burst.