Nasus has no early mobility, so he can't escape the Demacian Standard (E)-Dragon Strike (Q) knock-up all-in, and his Siphoning Strike (Q) stack farming keeps getting interrupted, ceding the lane.

Sion has no dash and his Decimating Smash (Q) charges slowly, so he can't dodge the Demacian Standard (E)-Dragon Strike (Q) gap-close all-in and loses every trade.

Before level 5 Kayle has no dash, and Celestial Blessing (W)'s heal alone can't survive the burst, so she collapses to the Demacian Standard (E)-Dragon Strike (Q) knock-up one-shot all-in.

Kassadin's melee trading is weak before 5, so he keeps ceding the lane to Demacian Standard (E)-Dragon Strike (Q) poke and knock-up all-ins.

Vladimir's early poke costs his own health, so during Sanguine Pool (W) cooldown he's repeatedly punished by the Demacian Standard (E)-Dragon Strike (Q) burst all-in.

Renekton's Slice and Dice (E) double dash and empowered Ruthless Predator (W) stun dominate early trades, and his Reign of Anger (P) sustain lets him trade back into the Demacian Standard (E)-Dragon Strike (Q) combo.

Darius uses Apprehend (E) to turn your Demacian Standard (E)-Dragon Strike (Q) engage against you, and his Decimate (Q) outer-blade heal plus 5-stack Hemorrhage (P) crush extended trades.

Fiora's Riposte (W) nullifies the Demacian Standard (E)-Dragon Strike (Q) knock-up and the Cataclysm (R) arena, and her Duelist's Dance (P) vitals give her the duel edge.

Pantheon's guaranteed Shield Vault (W) stun and Comet Spear (Q) poke keep battering the early lane before Jarvan can close the gap.

Jax's Counter Strike (E) dodges and stuns through the Demacian Standard (E)-Dragon Strike (Q) combo and autos, seizing the late-game duel edge.